Under certain circumstances, the game can clobber its own data files, for example killing or vampirizing Mrs. Crumplebottom. Certain modding tools can be misused to produce the same effect, such as modifying resources in situ rather than cloning them. Apparently, BodyShop itself can be used to delete the ugly Maxis clothes, destroying the data files containing them in the process.
To prevent this:
Your files are now safe from the game, yourself, and BodyShop!
Zirconia Wolf also suggests doing this procedure on your Downloads folder. That's My Documents/EA Games/The Sims 2/Downloads, not any other file or folder associated with the game, and definitely not the Neighborhoods folder, or your game won't be able to Save!
When to reverse this: Remember to unprotect the files before applying a Maxis patch or uninstalling the game.